CCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis
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چکیده
منابع مشابه
CCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis
INTRODUCTION Patients with rheumatoid arthritis (RA) can be separated into two major subpopulations based on the absence or presence of serum anti-citrullinated protein antibodies (ACPAs). The more severe disease course in ACPA(+) RA and differences in treatment outcome between these subpopulations suggest that ACPA(+) and ACPA(-) RA are different disease subsets. The identification of T-helper...
متن کاملA genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis
BACKGROUND Rheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA). Until now, data from genome-wide association studies (GWAS) have only been published from ACPA-positive subsets of RA or from studies that have not separated the two subsets. The aim of the current study is to provide and compare GWA...
متن کاملThe Infectious Basis of ACPA-Positive Rheumatoid Arthritis
Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs). ACPAs precedes the onset of clinical and subclinical RA. There are strong data for three infectious agents as autoimmunity triggers in RA, namely Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans causes of periodontal disease (PD), and Epstein...
متن کاملProtection against anti- citrullinated protein antibody- positive rheumatoid arthritis is predominantly associated with hlA-Drb1*1301 A meta-analysis of HLA-DRB1 associations with ACPA- positive and ACPA-negative rheumatoid arthritis in four European populations
objective The protective effect of HLA-DRB1 alleles on the development of rheumatoid arthritis (RA) is poorly understood. We performed a meta-analysis of four European populations to investigate which HLA-DRB1 alleles are associated with protection in anticitrullinated protein antibody (ACPA)-positive and ACPA-negative RA. methods More than 2800 patients and 3000 controls with information on HL...
متن کاملACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial
INTRODUCTION UK guidelines recommend that all early active rheumatoid arthritis (RA) patients are offered combination disease-modifying antirheumatic drugs (DMARDs) and short-term corticosteroids. Anti-citrullinated protein antibody (ACPA)-positive and ACPA-negative RA may differ in their treatment responses. We used data from a randomized controlled trial - the Combination Anti-Rheumatic Drugs...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2015
ISSN: 1478-6354
DOI: 10.1186/s13075-015-0800-5